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#R9613
Membrane Potential Demo Sheet

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LifeSciTRC Nernst Goldman Scenarios Resubmit.xlsx

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Description

I provide this excel sheet for students with my assignments and course materials on membrane potential. I believe these exercises help them appreciate the changes in membrane potential due to changes in permeability of the membrane. However, this is not intended to substitute for manual quantitative and calculation skills that students need to master. In some cases, you as the instructor must explain why intervening events prevent a particular value from ever being realized. Examples: -Na channel inactivation prevents the membrane potential from ever reaching the Nernst potential for Na of +60 mV. -K channel inactivation prevents the membrane potential from ever reaching the Nernst potential for K of -90 mV -Also, emphasize the last two scenarios. GABA transmission doesn't greatly alter Vm at rest (because Vm is at the equilibrium potential for Cl. However, when the normal stimulus (glutamate) to reach threshold is input along with GABAergic stimulation, action potential firing is effectively blocked by failing to reach threshold. You can also ask students to come up with (write about) another scenario and what the membrane potential might be under those conditions. In that case, I would give them less scenarios ahead of time than are available in the document.

Type of Resource

Assignment/Activity (Non-Laboratory/Non-Hands on Activity)

Format

Excel Spreadsheet (2007) - XLSX

Technical Note

Microsoft Excel

Author

Dave Knight, Christopher Newport University