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#R8319
Ribosome Assembly

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Shockwave Flash
APS
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Description This submission is a component of a series of animated lessons explaining various aspects of protein translation. The other components, submitted separately, are Protein Translation Overview, Protein Translation PA Sites, Peptidyl Transferase Activity, Transfer RNA, Genetic Code, Nuclear Pore Complexes, Nucleolus, Rough ER Targeting and Protein Sorting. This simple animated lesson outlines the steps of ribosomal RNA (rRNA) processing and ribosome assembly. It begins with an image of an rRNA gene cluster. It then shows the transcription of a polycistronic pre-rRNA, cleavage of intervening sequences to release the 18S, 5.8S and 28S rRNAs, transcription of 5S rRNA from separate genes, and association of ribonucleoproteins with the rRNAs to form the small and large ribosomal subunits. The animation serves as a valuable resource for any collegiate-level course that presents ribosomal synthesis. Courses that might employ it include Introductory Biology, Molecular Biology, Biochemistry and Genetics. Two modes are provided for each lesson, “Labeled” and “PopUp.” Users can toggle between the modes at any point in a lesson. In the "Labeled" mode titles, labels and explanatory text accompany the images. The explanatory text makes an animation useful for self-study. To make an animation appropriate as a visual aid for lectures the explanatory text can be toggled off, thereby preventing it from competing with an instructor’s verbal explanations. The “PopUp” mode is designed to summarize key points, making it particularly conducive to self-study. Information appears when the cursor is passed over an object. In many cases additional information appears when the object is clicked.
Type of Resource Animation
Format Shockwave Flash - SWF
Technical Note Flash-enabled web browser To open the animations with a Windows operating system using Internet Explorer follow these steps: (1) Click the link for the animation. (2) A dialog box may pop up that begins with the statement "Windows cannot open this file:" If this box does not appear proceed to step four. If it does choose "Select the program from a list," then click OK. (3) Another dialog box will pop up that lists different programs. Make sure "Internet Explorer" is selected, then click OK. (4) Internet Explorer will pop up. Beneath the toolbars at the top of the window a yellow bar will appear that reads "To help protect your security, Internet Explorer has restricted this webpage from running scripts or Active X controls that could access your computer. Click here for options..." Pass the cursor over this yellow bar and click the right mouse button. (5) A dialog box will pop up. Left click the option "Allow Blocked Content." (6) Another dialog box will appear labeled "Security Warning" asking you to confirm that you want to run the content. Click "Yes." (7) The Flash animation will appear in the Internet Explorer Window. (8) Instructions for navigating the lesson are provided by the first frame of the animation. On most screens unless specified, clicking anywhere on the screen advances the action. To open the animations with a MAC operating system, click the link for the animation. If the .swf doesn't open it may have gone to your downloads file. If so, find your downloads file (home folder?), open your browser: File: Open File: select the title from downloads: open. It should open in your browser.
Author
Jack Thatcher, West Virginia School of Osteopathic Medicine
Development Date June 25, 2013
Grade/Age Levels Undergraduate lower division (Grades 13-14)
Undergraduate upper division (Grades 15-16)
Graduate
Professional (degree program)
Pedagogies
Learning Time <=1 hour
Language English
Type of Review Reviewed By LifeSciTRC Board
Review Date November 18, 2013
Keywords
Suggested Use

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This animation is a component of a series of animated lessons explaining various aspects of protein translation.  These are difficult concepts that students often find difficult to grasp. The entire series serves as a valuable resource for any collegiate-level course that presents protein translation because of its unique ability to convey complex information in an animated visual format.

Johana Vallejo, Midwestern University


Animations by this instructor are execellent learning tools.  The contributor has submitted several animations in a series.  These are of the highest quality animations I have seen along with those that are manufactured by book publishers.  Excellent concept and excellent presentation.

Elissa Carney, American Physiological Society


Very clear, nicely done

Thomas Schmidt, UIowa