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Inflammation and Stem Cells in Gastrointestinal Carcinogenesis

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Description Chronic inflammation-induced carcinogenesis is a commonly accepted entity and is frequently seen within the gastrointestinal tract, although the underlying mechanisms remain unclear. Alterations in specific oncogenes and tumor suppressor genes are known to be responsible for malignant transformation. Nevertheless, the inflammatory microenvironment classically affects tumor promotion in its role as an altered stem cell niche and can also affect tumor initiation and tumor progression. The origin of the tumor cells is often attributed to stem cells, a unique subpopulation within tumors that possess the ability to initiate tumor growth and sustain self-renewal, as well as is largely responsible for their metastatic potential. Here, we review the link between inflammation and gastrointestinal carcinogenesis and the relationship between stem cells and cancer stem cells.
Type of Resource Journal Article/Issue
Format Web Page - HTML
Michael Quante, Columbia University Medical Center
Timothy Wang, Columbia University Medical Center
Development Date December 1, 2008
Grade/Age Levels Undergraduate lower division (Grades 13-14)
Undergraduate upper division (Grades 15-16)
Professional (degree program)
Continuing Education
General Public
Informal Education
Learning Time <=1 hour
Language English
Type of Review Reviewed By Journal Board
Review Date Reviewed at time of publication
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